Research that have led to Immune System participation in the pathology of Hypertension are relatively new. Association between HTA and renal disease was reported on 1879 and the first description of autoimmunity as producing morbid situation appeared on 1904 when the antibodies description causing hemolytic anemia in the crio hemoglobin paroxysmic where the end of the stated situation by Paul Erlich who established that the organism didn’t hurt himself (horror autotoxicus) Pioneer observations about participation in experimental models in HTA started to re appear at the end of the last century , however it has been in the last few decades when an increasingly number of researches have led to stablish in an unmistakable manner the critical role of autoimmunity in the complex etic pathogenic mechanism which results in the elevation of HTA Inflammation as manifestation of the immune reactivity of hypertension arterial Inflammation as a demonstration of the immune reactivity of Hypertension Arterial. It is very well established that the kidneys inflammation, in the arterial wall and the central nervous system helps development and increases severity of the hypertension.