Journal of Allergy & Therapy is a peer-reviewed journal covers a broad spectrum of topics, including allergy, allergic rhinitis, asthma, drug allergies, atopic dermatitis, clinical immunology, hypersensitivity, saliva allergy, reactive airways dysfunction syndrome, irritant-induced asthma, reactive attachment disorder (RADS) syndrome, oil and vitamin-associated inflammation, allergy-associated skin tests and their interpretation, allergy test results scale, ethanol-associated allergy, chronic obstructive pulmonary disease, and more. Atopic disease is a multifactorial chronic disorder that can evolve from one another and have overlapping etiological mechanisms.

Atopic dermatitis is most often the first step in the development of atopic dermatitis and represents a major socio-economic burden in developed countries. Treatment of atopic dermatitis is often time consuming and in some cases less effective than expected. Stratification of patient populations according to the clinical phenotype of the disease and specific measurable values (biomarkers) helps identify the most important etiologic mechanisms of the disease in these populations. This increases the predictive value of the evolution of the disease and allows the use and exploration of more targeted therapies to prevent this evolution and comorbidities. Asthma is a long-term condition that affects both children and adults. Approximately 300 million people worldwide suffer from asthma, and it is estimated that another 100 million will be affected by 2025. Atopic asthma is the most common form of asthma, affecting 70-90% of children and 50% of adult patients. AD is associated with Food Allergies (FA), asthma, and Allergic Rhinitis (AR), with or without elevated IgE levels. This gradual transition from one atopic disease to another over a nearly specific age range is called an atopic march. AD is considered to be the first step because disorders of the skin barrier, inflammation, and bacterial dysbiosis. Cause the sensitization required for the development of other atopic disorders.

However, AD can follow asthma and AR. FA develops early in life, can occur before or after AD, and in some cases can be the first sign of an atopic march. The actual pathogenesis of bronchial allergies and AD isn't always completely understood. Both illnesses are related to continual inflammation. In bronchial allergies sufferer’s cytokines and different inflammatory mediators are observed in bronchial washings. Both illnesses may be IgE- mediated which shows genetic predisposition as atopy refers back to the familial tendency to supply Ig-E. Imbalance withinside the Th1/Th2 ratio is related to better manufacturing of IgE in atopic sufferers. By generating Il-2 and Il-13, Th2 cells sell the manufacturing of IgE with the aid of using B-cells in reaction to antigen trigger. In addition to allergic comorbidities, AD and asthma are associated with non-allergic diseases.

Comorbidities of non-allergic AD consist of skin and extra cutaneous infections, neuropsychiatric disorders, obesity, cardiovascular disease, and some cancers. Interventions to reduce the severity of childhood illness suggest that they may have protective functions against the development of these comorbidities. Disruption of the skin barrier is a major factor in the development of atopic diseases, as trans epidermal penetration of antigens leads to sensitization. For this reason, AD almost always precedes asthma. Allergic asthma is the most common type of asthma and is usually defined by the presence of sensitization to environmental allergens