In an attempt to understand mediating mechanisms following personal research in Stress and personality and further involvement in a mortality study and it seemed imperative to further elucidate mechanisms involving self-defeating ideation [1-4]. Нe global socio economic statistics associated with depression, and suicide, not to mention the personal and family suوٴerLnJ and consequences are alarming. Нe relationship between stress and personality became accepted showing that stress was activated internally by cognition [1]. Нe mortality following a clinically depressed cohort showed the alarming premature mortality which followed a diagnosis of depression from natural death, particularly in the early years Dіer discharge. While it is widely accepted that unnatural death is associated with premature mortality, it is less accepted that death from natural causes contributes to the total premature mortality following depression